New chemistry of organotitanium compounds

• "Titanium-mediated carbonyl olefinations. 1. Methylenations of carbonyl compounds with dimethyltitanocene," Petasis, N. A.; Bzowej, E. I. J. Am. Chem. Soc., 1990, 112, 6392.

• "Titanium-mediated carbonyl olefinations. 2. Benzylidenations of carbonyl compounds with dibenzyl titanocene," Petasis, N. A.; Bzowej, E. I. J. Org. Chem., 1992, 57, 1327.

• "Titanium-mediated carbonyl olefinations. 3. Conversion of carbonyl compounds to vinyl silanes," Petasis, N. A.; Akritopoulou, I. Synlett, 1992, 665.

• "Biscyclopropyltitanocene: A novel reagent for the synthesis of alkylidene and vinyl cyclopropanes," Petasis, N. A.; Bzowej, E. I. Tetrahedron Lett., 1993, 34, 943.

• "Reactions of dimethyl titanocene with alkynes and nitriles," Petasis, N. A.; Fu, D. -K. Organometallics, 1993, 13, 3776.

• "Ring-opening metathesis polymerization of norbornene with titanium alkylidenes generated by thermolysis of dimethyltitanocene and related cyclopentadienyl itanium(IV) derivatives," Petasis, N. A.; Fu, D. -K. J. Am. Chem. Soc., 1993, 115, 7208.

• "Methylenations of heteroatom-substituted carbonyls with dimethyl titanocene," Petasis, N. A.; Lu, S. -P. Tetrahedron Lett., 1995, 36, 2393.

• "Tris(trimethylsilyl) titanacyclobutene: A new mild reagent for the conversion of carbonyls to alkenyl silanes," Petasis, N. A.; Staszewski, J. P.; Fu, D. -K. Tetrahedron Lett., 1995, 36, 3619.

• "Titanium-mediated olefinations of cyclobutenedione derivatives," Petasis, N. A.; Hu, Y. -H.; Fu, D. -K., Tetrahedron Lett., 1995, 36, 6001.

• "Organotitanium compounds in organic synthesis," Petasis, N. A.; Lu, S. -P.; Bzowej, E. I.; Fu, D. -K.,Staszewski, J. P.; Akritopoulou-Zanze, I.; Patane, M. A.; Hu, Y. -H. Pure & Appl. Chem., 1996, 68, 667.

• "Allenation of carbonyl compounds with alkenyl titanocene derivatives," Petasis, N. A.; Hu, Y. -H. J. Org. Chem., 1997, 62, 782.

• "Cyclopentadienyl titanium derivatives in organic synthesis," Petasis, N. A.; Hu, Y. -H. Current Organic Chemistry, 1997, 1, 249.

New chemistry of organoboron compounds

• "The boronic acid Mannich reaction: A new method for the synthesis of geometrically pure allylamines," Petasis, N. A.; Akritopoulou, I. Tetrahedron Lett., 1993, 34, 583.

• "Mild conversion of alkenyl boronic acids to alkenyl halides with halosuccinimides," Petasis, N. A.; Zavialov, I. A. Tetrahedron Lett., 1996, 37, 567.

• "A new and practical synthesis of alpha-amino acids from alkenyl boronic acids," Petasis, N. A.; Zavialov, I. A. J. Am. Chem. Soc., 1997, 119, 445.

• "A new synthesis of alpha-arylglycines from aryl boronic acids," Petasis, N. A.; Goodman, A.; Zavialov, I. A. Tetrahedron, 1997, 53, 16463.

• "Facile preparation of fluorine-containing alkenes, amides and alcohols via the electrophilic fluorination of alkenyl boronic acids and trifluoroborates," Petasis, N. A.; Yudin, A. K.; Zavialov, I. A.; Prakash, G. K. S.; Olah, G. A. Synlett, 1997, 606.

• "Mild preparation of haloarenes by ipso-substitution of arylboronic acids with N-halosuccinimides," Thiebes, C.; Prakash, G. K. S.; Petasis, N. A.; Olah, G. A. Synlett, 1998, 141.

• "Highly stereocontrolled one-step synthesis of anti-beta-amino alcohols from organoboronic acids, amines and alpha-hydroxy aldehydes," Petasis, N. A.; Zavialov, I. A. J. Am. Chem. Soc., 1998, 120, 11798.

• "A Facile stereocontrolled synthesis of anti-a-(trifluoromethyl)- b-amino alcohols," Prakash, G. K. S.; Mandal, M.; Schweizer, S.; Petasis, N.A.; Olah, N. A. Org. Lett., 2000, 2, 3173.

• "Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids, " Petasis, N. A.; Patel, Z. D. Tetrahedron Lett., 2000, 41, 9607.

New Synthetic Methods and Strategies

• "Synthesis of 8-membered ring lactones from dioxolenones," Petasis, N. A.; Patane, M. A. J. Chem. Soc., Chem. Commun, 1990, 836.

• "A Claisen rearrangement strategy for the three-atom ring expansion of cyclic ketones. A total synthesis of (±) precapnelladiene," Petasis, N. A.; Patane, M. A. Tetrahedron Lett, 1990, 31, 6799.

• "The synthesis of carbocyclic eight-membered rings," Petasis, N. A.; Patane, M. A. Tetrahedron, 1992, 48, 5757.

• "Enolates of alpha-allenyl ketones: Formation, relative stability and reactivity of cumulenolates," Petasis, N. A.; Teets, K. A. J. Am. Chem. Soc., 1992, 114, 10328.

• "A new synthetic approach to enediynes related to the neocarzinostatin chromophore from alpha-allenyl carbonyl compounds," Petasis, N. A.; Teets, K. A. Tetrahedron Lett., 1993, 34, 805.

• "Alicyclic Claisen rearrangement with a two-atom ring contraction. A new synthetic approach to cembranoids," Petasis, N. A.; Bzowej, E.I. Tetrahedron Lett., 1993, 34, 1721.

• "Investigations of the formation of cyclic acetal and ketal derivatives of D-ribono-1,4-lactone and 2-deoxy-D-ribono-1,4-lactone," Han, S. Y.; Joullie, M. M.; Petasis, N. A.; Bigorra, J.; Corbera, J.; Font, J.; Ortuno, R. M. Tetrahedron, 1993, 49, 349.

• "Spectroscopic, crystallographic and computational studies of the formation and isomerization of cyclic acetals and ketals of pentonolactones," Han, S. Y.; Joullie, M. M.; Fokin, V. V.; Petasis, N. A. Tetrahedron Asymmetry, 1994, 5, 2535.

• "New stereocontrolled synthesis of substituted tetrahydrofurans from 1,3-dioxolan-4-ones," Petasis, N. A.; Lu, S. -P. J. Am. Chem. Soc., 1995, 117, 6394.

• "Stereocontrolled synthesis of substituted tetrahydropyrans from 1,3-dioxan-4-ones," Petasis, N. A.; Lu, S. -P. Tetrahedron Lett., 1996, 37, 141.

• "Synthesis of substituted benzonorbornadienes from cyclobutenediones," Petasis, N. A.; Fu, D. -K. Synlett, 1996, 155.

• "Formation of eight-membered ring beta-ketolactones via the intramolecular trapping of hydroxy acylketenes," Petasis, N. A.; Patane, M. A. Res. Chem. Intermed. 1996, 22, 781.

Lipoxins and other Lipids

• "Lipoxins and related eicosanoids. Biosynthesis, biological properties and chemical synthesis," Nicolaou, K. C.; Ramphal, J. Y.; Petasis, N. A.; Serhan, C. N. Angew. Chem. Int. Ed. Engl., 1991, 30,1110.

• "Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils," Serhan, C. N.; Maddox, J. F.; Petasis, N. A.; Akritopoulou-Zanze, I.; Papayianni, A.; Brady, H. R.; Colgan, S. P.; Madara, J. L. Biochemistry, 1995, 34, 14609.

• "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP- I cells via a G-protein linked lipoxin A4 receptor, " Maddox, J. F. ; Hachicha, M.; Takano, T.; Petasis, N. A.; Fokin, V. V.; Serhan, C. N. J. Biol. Chem., 1997, 272, 6972.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Aspirin-triggered 15-epi-Lipoxin A4 (LXA4) and LXA4 stable analogs are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors," Takano, T.; Fiore, S.; Maddox, J. F. ; Brady, H. R.; Petasis, N. A.; Serhan, C. N. J. Exp. Med., 1997, 185, 1693.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of P-selectin," Scalia, R.; Gefen, J. Petasis, N. A.; Serhan, C. N.; Lefer, A. M. Proc. Nat. Acad. Sci., 1997, 94, 9967.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "A role for polyisoprenyl phosphates in intracellular signaling," Levy, B. D.; Petasis, N. A.; Serhan, C. N., Nature, 1997, 389, 985.
  [Abstract]

• "Lipoxin B4 regulates human monocyte and neutrophil adherence and motility. Design of stable lipoxin B4 analogs with increased biologic activity," Maddox, J. F. ; Colgan, S.P.; Clish, C. P.; Petasis, N. A.; Fokin, V. V.; Serhan, C. N. FASEB Journal, 1998, 12, 487.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs," Takano, T.; Clish, C. B.; Gronert, K.; Petasis, N. A.; Serhan, C. N., J. Clin. Invest., 1998, 101, 819.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Pathogen-induced Chemokine Secretion from Model Intestinal Epithelium is Inhibited by Lipoxin A4 Analogs," Gewirtz, A. T.; McCormick, B.; Neish, A. S.; Petasis, N. A.; Gronert, K.; Serhan, C. N.; Madara,J. L., J. Clin. Invest., 1998, 101, 1860.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Aspirin triggered 15-epi-LXA4 (ATL) generation by human leukocytes and murine peritonitis exudates: Development of a specific 15-epi-LXA4 ELISA," Chiang, N.; Takano, T.; Clish, C. B.; Petasis, N. A.; Tai, H. T.; Serhan, C. N., J. Pharmacol. Exper. Therap., 1998, 287, 779.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a "stop" signaling switch for aspirin-triggered lipoxin A4," Levy, B. D.; Fokin, V. V.; Clark, J. M.; Wakelam, M. O.; Petasis, N. A.; Serhan, C. N. FASEB Journal, 1999, 13, 903.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo,"" Clish, C. B.; OÕBrien, J. A.; Gronert, K.; Stahl, G.; Petasis, N. A.; Serhan, C. N. Proc. Natl. Acad. Sci. USA, 1999, 96, 8247.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages," Godson, C.; Mitchell, S.; Harvey, K.; Petasis, N. A.; Hogg, N.; Brady, H. R. J. Immunology, 2000, 164, 1663.
  [Abstract]  [Full Article-HTML]  [Full Article-PDF]

• "Lipoxin A4 analogues inhibit leukocyte recruitment to porphyromonas gingivalis: A role for cyclooxygenase-2 and lipoxins in periodontal disease," Pouliot, M.; Clish, C. B.; Petasis, N. A.; Van Dyke, T. E.; Serhan, C. N. Biochemistry, 2000, 39, 4761.

Books

• "Exercises and Problems of Organic Chemistry," Petasis, N. A., University Studio, Thessaloniki, Greece, 1977, 500 pp. (in Greek).

• "Selenium in Natural Products Synthesis," Nicolaou, K. C.; Petasis, N. A., CIS, Philadelphia, 1984, 300 pp.

Patents

• "A method for the olefination of carbonyl compounds with titanocene derivatives," Petasis, N. A.; Bzowej, E. I. US Patent, 5,087,790 (1992).
  [Description]

• "Method for the synthesis of amines and amino acids with organoboron derivatives," Petasis, N. A.; Zavialov, I. A. US Patent, 6,232,467 (2001).
  [Description]