A key feature of our multicomponent boron-based reactions is their ability to generate a large variety of potentially bioactive molecules. For this reason we are investigating a number of strategies that would allow the facile production of combinatorial libraries that may be of useful for pharmaceutical and agrochemical applications. These include the synthesis of novel amines, amino acids, amino alcohols, amino sugars, peptidomimetics, and various heterocyclic systems.

By relying on some unique features of our methodology involving organotitanium and organoboron compounds, we are also pursuing the design and synthesis of a variety of novel ligands for asymmetric synthesis and catalysis. Such systems are valuable for the rapid identification of novel catalysts for new or well-known organic transformations.