Gene Conversion Table
About this page: This table was intended to provide a quick translation from S. pombe to S. cerevisiae homologues prior to the genome publication and curation. It is no longer maintained but is left here because it may be helpful in some circumstances. For details and most up to date information, we suggest you go to genedb. There is also a group particularly interested in orthologues to which you can subscribe here: http://publists.sanger.ac.uk/mailman/listinfo/yeast_orthologous_groupFission yeast genes are listed alphabetically under just one name, but their aliases are listed alongside. If you can't find the gene you want in its alphabetical position, use the search feature of your browser to see if it is listed under a synonym. One yeast may have a pair of genes where the other has just one. These cases are indicated by the word "and"; otherwise multiple gene names are aliases. In a few cases, the same gene designation may have been used for different genes which we have noted.
Recall that just because there is a cerevisiae homologue of a pombe gene doesn't mean they work the same way, and that genes without primary sequence homology can be functional homologues.
| S. pombe gene and aliases | S. cerevisiae sequence homologue(s) | Fission yeast gene product or protein function | Metazoan homologue? (definitely incomplete!) |
|---|---|---|---|
| abp1+ | no homologue | CENP-B homologue; see cbh1+ and cbh2+ | Y |
| abt2+ | TUB3 | alpha tubulin (a2); not essential | Y |
| ade6+ | ADE2 | phosphoribosylaminoimidazole carboxylase | |
| alp2+ | SPC97 | gamma-tubulin interactor | |
| alp4+ | SPC98 | gamma-tubulin interactor | |
| alp6+ | GCP3 | gamma-tubulin interactor | |
| slp16+ | GCP6 | gamma-tubulin interactor | |
| apc10+ | APC10 | APC subunit | Y |
| ark1+ | IPL1 | Aurora kinase | Y |
| atb2+ alp2+ ban5+ tub1+ | TUB3 | alpha-2 tubulin; see also nda2+ | |
| btf3+ | EGD1 and BTT1 | binds nascent RNAs | |
| byr1+ ste1+ | STE7 | MAPKKK, pheromone signalling | Y |
| byr2+ | STE11 | MAPKK, pheromone signalling | Y |
| byr4+ | BYR4? | With Cdc16p, a two-component GEF for the GTPase spg1 (involved in cytokinesis) | |
| cbh1+ | no homologue | CENP-B homologue; see cbh2+ and apb1+ | Y |
| cbh2+ | no homologue | CENP-B homologue; see cbh1+ and abp1+ | Y |
| cdc1+ | HYS2/HUS2/POL31/SDP5 | DNA pol delta subunit | |
| cdc2+ | CDC28 | CDK | Y |
| cdc3+ | PFY1 | profilin | Y |
| cdc4+ | KAP122/PDR6 | myosin light chain | Y |
| cdc5+ | CEF1 | MYB-type splicing factor | Y |
| cdc6+ pol3+ pold+ | POL3 /CDC2 | DNA polymerase delta | Y |
| cdc7+ | CDC15 | septation kinase | |
| cdc8+ | TPM1 and TPM2 | tropomyosin | Y |
| cdc10+ | SWI6 | G1 phase transcription factor | |
| cdc11+ | NUD1 | required for cytokinesis | |
| cdc12+ | BNI1 | required for actin ring assembly | |
| cdc13+ | CLB1, CLB2, CLB3, and CLB4 | B type cyclin, M phase. Essential. | Y |
| cdc14+ | no homologue | required for septation | |
| cdc15+ | HOF1/YMR032wp | required for septation | |
| cdc16+ | BUB2 | checkpoint/cytokinesis protein. With Byr4, part of the GEF for spg1 | |
| cdc17+ | CDC9 | DNA ligase | Y |
| cdc18+ | CDC6 | S phase initiator / MCM loader | Y |
| cdc20+ pol2+ pole+ | POL2 | pol epsiolon | Y |
| cdc22+ | RNR1 | lg subunit ribonucleotide reductase | Y |
| cdc23+ | MCM10/DNA43 | S phase factor | |
| cdc24+ | no homologue | required for completion of S phase, possibly in Okazaki fragment maturation | |
| cdc25+ | MIH1 | CDK tyrosine phosphatase | Y |
| cdc27+ | POL32 | DNA pol delta subunit | |
| cdc28+ prp8+ | no homologue | helicase | |
| cdc45+ sna41+ goa1+ | CDC45 | replication initiation factor | Y |
| cdm1+ | no homologue?? | DNA pol delta subunit | |
| cds1+ | RAD53 | checkpoint kinase; not essential in pombe | Y |
| cdt1+ | TAH11/SID2 | required for replication initiation | Y |
| cek1+ | RIM15 | kinase | |
| cgs1+ | BCY1 | regulatory subunit of PKA | |
| cgs2+ pde1+ | PDE1 and PDE2 | cAMP phosphodiesterase | |
| chk1+ rad27+ | CHK1 | checkpoint kinase, damage response | Y |
| chp1+ | ? | chromodomain protein, required for centromere function | |
| chp2+ clo2+ | no homologue | chromodomain protein, related to Swi6p and HP1 | Y |
| cig1+ | ? | B-type cyclin, function not clear. Not essential. See cdc13+ | |
| cig2+ | CLB5 and CLB6 | B-type cyclin in S phase, not essential. See cdc13+ | |
| clp1+ cfh1+ flp1+ | CDC14 | phosphatase, involved in septation. Not essential in pombe | |
| clr1+ | no homologue | DNA binding protein | |
| clr3+ | HDA1 | histone deacetylase | |
| clr4+ | no homologue | histone H3 methyl transferase | Y; Drosphila Su(var) 3-9 |
| clr6+ | RPD3 | Histone deacetylase | Y |
| cmb1+ | no homologue | Mismatch and damage recognition/HMG protein | |
| cnd1+ | YCS4/LOC7 | condensin subunit; XCAP-D2 | Y |
| cnd2+ | BRN1 | condensin subunit; XCAP-H | Y |
| cnd3+ | YCG1/TIE1/YCS5 | condensin subunit; XCAP-G | Y |
| cnp1+ | CSE4 | CENP-A homologue; centromere specific H3 histone | Y |
| cps1+ drc1+ | GLS1 and GLS2 | 1,3-(beta)-glucan synthase. | |
| csk1+ | CAK/CIV1 | CAK-activating kinase | Y |
| csn1+ | no homologue | Signalosome subunit 1 | Y |
| csn2+ | no homologue | Signalosome subunit 2 | Y |
| csn4+ | no homologue | Signalosome subunit 4 | Y |
| csn5+ | RRI1 | Signalosome subunit 5 | Y |
| csn7+ | no homologue | Signalosome subunit 7 | Y |
| ctf18+ chl12+ | CTF18/CHL12 | RFC-1 related protein required for chromosome transmission | |
| ctr4+ | CTR1 and CTR3 | High affinity copper transporter | |
| cuf1+ | MAC1 | Copper-sensing transcription factor | |
| cuf2+ | no homologue? | Metal ion homeostasis protein | |
| cut1+ | ESP1 | promotes anaphase. Separin. | |
| cut2+ | PDS1 | APC substrate, blocks cut1. Securin. | |
| cut3+ | SMC4 | condensin, SMC4 subunit | Y |
| cut4+ | APC1 | APC subunit | Y |
| cut6+ | ACC1 | acetyl coA carboxylase | |
| cut7+ | CIN8 and KIP1 | kinesin | Y |
| cut8+ | DBF8 | ? regulates APC? | |
| cut9+ | CDC16 | APC subunit | Y |
| cut11+ | NDC1 | nuclear envelope protein at SPBs and NPCs | |
| cut12+ | no homologue | required for spindle formation | |
| cut14+ | SMC2 | condensin, SMC2 subunit | Y |
| cut17+ bir1+ | BIR1 | Bir1/Survivin, chromosomal passenger protein | Y |
| cut20+ lid1+ | APC4 | APC subunit | Y |
| cut23+ | CDC23/APC8 | TPR-protein, APC component | Y |
| cyr1+ git2+ | CYR1 | adenylate cyclase | |
| dfp1+ him1+ rad35+ | DBF4 | regulatory subunit of CDC7-type kinase | Y |
| dhc1+ | DYN1 | dynein motor protein | |
| dim1+ | DIB1 | Required for mitosis. Note the designation Dim1 was used later for a different gene encoding a dimethylase. | |
| dis1+ | STU1 | TOG-family microtubule associated proteins (also see Mtc1/Alp14) | Y |
| dis2+ | GLC7 | PPI-class phosphatase. Also see Sds21 | |
| dmc1+ | DMC1 | meiosis specific Rhp51 (RAD51) homologue, presumed required for meiotic pairing | |
| dna2+ | DNA2 | helicase | Y |
| drc1+ | DRC1/SLD2 | CDK target, binds Rad4/Cut5, required for S phase. | |
| eso1+ | CTF7/ECO1 (C-terminal) RAD30 (N-terminal) | Required for sister chromatid cohesion and possibly for repair. A gene fusion: the C-terminus looks like CTF7/ECO1, and the N-terminus looks like RAD30 | Y |
| exo1+ | EXO1 | Mismatch repair/5' to 3' exonuclease | |
| git3+ | GPR1 | G protein coupled glucose receptors | |
| gpa1+ | GPA1 | G protein alpha subunit in pheromone signalling | |
| gtb1+ | TUB4 | gamma tubulin | |
| hcn1+ | CDC26 | APC subunit | |
| hda1+ hoc1+ phd1+ | RPD3 | histone deacetylase; related to clr6+ | |
| his1+ | HIS1 | ATP phosphoribosyltransferase | |
| his2+ | HIS4C | histidinol dehydrogenase | |
| his3+ | HIS5 | histidinol-phosphate aminotransferase | |
| his5+ | HIS3 | imidazoleglycerol-phosphate dehydratase | |
| his7+ | HIS4A | phosphoribosyl-AMP cyclohydrase | |
| hhp1+ and hhp2+ | HRR25 | CK-related kinases; role in repair? | |
| hsk1+ | CDC7 | DDK: DBF4-Dependent Kinase | Y |
| hus1+ | MEC3 | Checkpoint factor, also in metazoans. Complex with rad1, 9 | Y |
| ibp1+ | YGR203W | small Cdc25-like phosphatase | ? |
| imp1+ | SPR1 | nuclear transport factor | |
| kap104+ | KAP104 | nuclear transport factor | |
| kap114 | KAP114 | nuclear transport factor | |
| klp2+ | KAR3 | kinesin motor; redundant with pkl1+ | |
| klp3+ | no homologue | kinesin motor | |
| klp5+ and klp6+ | KIP3 | kinesin motors involved in MT dynamics | |
| klp7+ | no homologue | kinesin motor | |
| klp8+ | no homologue | kinesin motor | |
| leu1+ | LEU2 | beta-isopropylmalate dehydrogenase | |
| lys1+ | LYS2 | alpha-aminoadipate reductase | |
| mal3+ | BIM1 | EB1 homologue | Y |
| mcm2+ cdc19+ nda1+ | MCM2 | MCM complex subunit | Y |
| mcm3+ | MCM3 | MCM complex subunit | Y |
| mcm4+ cdc21+ | MCM4/CDC54 | MCM complex subunit | Y |
| mcm5+ nda4+ | MCM5/CDC46 | MCM complex subunit | Y |
| mcm6+ mis5+ | MCM6 | MCM complex subunit | Y |
| mcm7+ | MCM7/CDC47 | MCM complex subunit | Y |
| mcs2+ | CCL1 | cyclin H, forms CAK with mcs6; essential for viability | Y |
| mcs4+ | SSK1 | response regulator | |
| mcs6+ mop1+ crk1+ | KIN28 | CDK7, forms CAK (CDK-activating kinase) | Y |
| mdm12+ | MDM12 | mitochondrial morphology/inheritance component | |
| mek1+ | MEK1 | Meiosis-specific Cds1 (RAD53) homologue | |
| mei2+ | no homologue | RNA binding protein required for meiosis | |
| mei3+ | no homologue | activator of meiosis: inhibits Pat1 kinase | |
| meu13+ | HOP2 | Required for meiotic recombination and pairing | |
| mik1+ | SWE1 | CDK tyrosine kinase. Overlaps with wee1+; both are related to SWE1. | |
| mis4+ | SCC2 | adherin; required for cohesin to associate with chromatin | |
| mis6+ | CTF3 | inner centromere protein | |
| mis12+ | MTW1 | inner centromere protein | |
| mph1+ | MPS1 | kinase, part of spindle checkpoint | |
| mpr1+ ypd1+ | YPD1 | response regulator phosphotransferase | |
| mrc1+ | MRC1 | Checkpoint/replication factor, works with Cds1 | claspin |
| msh2+ swi8+ mut3+ | MSH2 | Mismatch repair/mating-type switching | Y |
| msh6+ | MSH6 | Mismatch repair | Y |
| mst1+ | ESA1 | MYST-family histone acetyltransferase | Y |
| mst2+ | SAS2 and SAS3 | MYST-family histone acetyltransferase | Y |
| mtc1+/alp14+ | STU1 | TOG-family microtubule associated proteins (also see dis1+) | Y |
| mts2+ | YTA1 | proteosome subunit | |
| mts3+ | NIN1 | proteosome subunit | |
| mus81+ | MUS81 | involved in recombination | |
| nda2+ | TUB1 | major alpha tubulin | Y |
| nda3+ | TUB2 | beta tubulin | Y |
| ndc80+ | NDC80 | centromere-associated spindle component | Y, human HEC |
| nim1+ cdr1+ | no homologue? | kinase regulates wee1 | |
| nuc2+ | CDC27 | APC subunit | Y |
| nuf2+ | NUF2 | centromere-associated spindle component | Y |
| nup40+ | NUP53 | Nucleoporin | |
| nup189+ | NUP145 | nucleoporin | |
| orp1+ | ORC1 | Origin Recognition Complex subunit | Y |
| orp2+ | ORC2 | Origin Recognition Complex subunit | Y |
| orp3+ | ORC3 | Origin Recognition Complex subunit | Y |
| orp4+ | ORC4 | Origin Recognition Complex subunit | Y |
| orp5+ | ORC5 | Origin Recognition Complex subunit | Y |
| orp6+ | ORC6 | Origin Recognition Complex subunit | Y |
| pat1+ | no homologue? (loosely related to SKS1 and other PKs) | essential kinase inhibitor of meiosis | |
| pch1+ | no homologue? | C-type cyclin, essential for viability | Y, C type cyclins |
| pcn1+ | POL30 | PCNA | Y |
| php2+ | HAP2 | carbon-source responsive transcription factor | |
| php5+ | HAP5 | carbon-source responsive transcription factor | |
| pic1+ | SLI15 | INCENP kinetochore protein | Y |
| pin1+ | ESS1 | prolyl isomerase | Y |
| pka1+ | TPK1, TPK2 and TPK3 | protein kinase A | Y |
| pkl1+ | KAR3 | kinesin motor; redundant with klp2+ | |
| pms1+ mlh1+ | PMS1 | mismatch repair protein | Y |
| pob1+ | BOI1 and BOI2 | required for cytokinesis | |
| pol1+ swi7+ pola+ | POL1/CDC17 | DNA polymerase alpha | Y |
| pop1+ | CDC4 | like sud1+; SCF | |
| pot1+ | no homologue? | protects telomere ends | Y |
| ppe1+ | SIT4 | protein phosphatase | |
| prp2+ | MUD2 | large subunit splicing factor U2AF | |
| prp4+ | no homologue | kinase required for splicing | |
| prp31+ | PRP31 | splicing factor | Y |
| psm1+ smc1+ | SMC1 | cohesin subunit | Y |
| psm3+ smc3+ | SMC3 | cohesin subunit | Y |
| psc3+ | SCC3 | cohesin subunit | Y |
| puc1+ | CLN3?? | cyclin, not essential. Acts in G1 at cell cycle entry/exit | |
| rad1+ | RAD17 | Checkpoint factor | Y |
| rad2+ | RAD27, RTH1 | FEN1 nuclease | Y |
| rad3+ | MEC1 | ATR(ATM) checkpoint kinase | Y |
| rad4+ cut5+ | DPB11 | checkpoint and replication factor | Y; TopBP1 or XMus101 |
| rad9+ | DDC1 | Checkpoint factor | Y |
| rad11+ rpa1+ ssb1+ | RPA1 | large subunit RPA | Y |
| rad13+ | RAD2 | excision repair protein | |
| rad15+ rhp3+ rad5+ | RAD3 | TFIIH subunit involved in NER and transcription | |
| rad16+ rad10+ rad20+ swi9+ | RAD1 | NER protein | |
| rad17+ | RAD24 | checkpoint protein, RFC1 related | |
| rad18+ | RHC18 | SMC-like protein involved in several repair processes | |
| rad21+ | MCD1 | cohesin | Y |
| rad22+ and rti1+ | RAD52 | RAD52 recombination proteins | Y |
| rad24+ | BMH1 | 14-3-3 protein | Y |
| rad25+ | BMH2 | 14-3-3 protein | |
| rad26+ | DDC2 | checkpoint factor | |
| rad32+ | MRE11 | Repair nuclease | Y |
| ras1+ | RAS1 and RAS2 | ras homologue, not essential | Y |
| rdh54+ | RDH54, TID1 | meiosis specific Rhp54 (RAD54) homologue | Y |
| rec8+ | REC8 | meiotic cohesin, rad21+ homologue | |
| rec12+ | SPO11 | meiotic early-recombination protein | |
| rep1+ | no homologue? | meiosis-activator of cdc10 transcription factor | |
| rep2+ | no homologue? | activator of cdc10 transcription factor | |
| res1+ sct1+ | SWI4 | partner to cdc10 transcription factor | |
| res2+ | MBP1 | partner to cdc10 transcription factor | |
| rfc1+ | RFC1 | Replication factor -C large subunit | Y |
| rfc3+ | RFC3 | Replication factor -C subunit 3 | Y |
| rhp4a+ and
rhp4b+ Incorrect nomenclature Recommended is rhp41 and 42 | RAD4 | nucleotide-excision repair | |
| rhp6+ | RAD6 UBC2 | repair protein | Y |
| rhp9+ crb2+ | RAD9 | Checkpoint protein | Y? |
| rhp14+ | RAD14 | nucleotide-excision repair | |
| rhp16+ | RAD16 | NER protein | |
| rhp26+ | RAD26 | NER protein, SWI2/SNF2 family | Y |
| rhp51+ | RAD51 | recombination repair | |
| rhp54+ | RAD54 | recombination repair | |
| rhp55+ | RAD55 | recombination repair | |
| rpa2+ ssb2+ | RPA2 | RPA subunit | Y |
| rpa3+ ssb3+ | RPA3 | RPA subunit | |
| rqh1+ rad12+ hus2+ | SGS1 | RecQ type helicase, BLM/WRN homologue | Y |
| rti1+ | no homologue | 2nd RAD52 homologue | |
| rum1+ | no homologue | CDK inhibitor; functionally similar to SIC1 | |
| sds1+ | GLC7 | PPI-class phosphatase (see dis2) | |
| sfc1+ | TFC1 | TFCIII subunit required for polIII transcription | |
| sfc3+ | TFC3 | TFCIII subunit required for polIII transcription | |
| sfc4+ | TFC4 | TFCIII subunit required for polIII transcription | |
| sfc6+ | TFC6 | TFCIII subunit required for polIII transcription | |
| sid2+ | DBF2 and DBF20 | kinase, for septation/cytokinesis | |
| skb1+ | HSL7 | protein methyltransferase | Y |
| skp1+ gsk3+ | GSK3 | glycogen synthase kinase | Y |
| sla1+ | LHP1 | La protein binds nascent pol III transcripts | |
| sld3+ | SLD3 | Replication factor | |
| slm9+ | HIR2 | Synthetic lethal with cdc25 | |
| slp1+ | CDC20 | APC activator (Fizzy) | Y |
| SPAC1B1.03c | KAP95 | nuclear transport factor | |
| SPCC1322.06 | KAP120 | nuclear transport factor | |
| SPAC22G7.02 | KAP122 | nuclear transport factor | |
| SPBC14F5.03C | KAP123 | nuclear transport factor | |
| sal3+ | PSE1 KAP121 | nuclear transport factor | |
| SPBC30B4.05 | CSE1 | nuclear transport factor | |
| SPCC18B5.07c | NUP2 | nucleoporin | |
| SPAC22G7.09c | NUP49 | nucleoporin | |
| SPBC19G7.15 | NUP57 | nucleoporin | |
| SPBC428.01c | NUP84 | nucleoporin | |
| SPBC17G9.04c | NUP85 | nucleoporin | |
| SPBC3B9.16c | NUP120 | nucleoporin | |
| SPAC1805.04 | NUP133 | nucleoporin | |
| SPAC23D3.06c | NUP159 | nucleoporin | |
| SPCC290.03c | NUP192 | nucleoporin | |
| SPAC26A3.15c | NSP1 | nucleoporin | |
| SPAC15F9.02 | SEH1 | nucleoporin | |
| SPBC28F2.02 | YOR091W | Nuclear pore complex-associated | |
| SPCC162.08 | MLP1 | Nuclear pore complex-associated | |
| SPAC2C4.11c | YOR145C | Nuclear pore complex-associated | |
| SPCC4B3.07 | YOR051W | Nuclear pore complex-associated | |
| spc1+ sty1+ phh1+ | HOG1 | MAPK, downsream of 2 component response regulator | |
| spc24+ | SPC24 | centromere-associated spindle component | |
| spg1+ | TEM1 | GTPase, involved in septation and mitotic exit | |
| spk1+ | FUS3 | MAPK, pheromone signalling | |
| SPAC3C7.06c | IME2 ? | putative protein kinase | |
| srw1+ ste9+ | HCT1/CDH1 | APC activator, WD protein | |
| suc1+ | CKS1 | small CDK associated protein | Y |
| suc22+ | RNR2 | small subunit ribonucleotide reductase | |
| sud1+ | CDC4 | like pop1+; SCF | |
| swi1+ | TOF1 | required for mating type switching and replication fork pausing | |
| swi3+ | CSM3 | required for mating type switching and replication fork pausing | |
| swi4+ | MSH3 | Mating-type switching | |
| swi5+ | SAE3 | Mating-type switching, recombination in meiosis and mitosis | Y |
| swi6+ | no homologue | chromodomain protein, HP1 related | Y |
| swi10+ | RAD10 | NER and mating-type switching | |
| taz1+ | no homologue? | binds telomeres; pombe equivalent of TRF1/2? | Y |
| tea1+ | no homologue? | involved in cell polarity | |
| tea2+ | KIP2 | kinesin motor/cell morphology | |
| tel1+ | TEL1 | ATM-related kinase (see rad3+) | |
| trt1+ | EST2 | catalytic subunit of telomerase | |
| tup11+ and tup12+ | TUP1 | co-repressor proteins | |
| uap2+ | CUS2 | U2 snRNP associated protein | |
| ura4+ | URA3 | orotidine 5'-phosphate decarboxylase | |
| wee1+ | SWE1 | CDK tyrosine kinase. Not essential. Overlaps with mik1+ | Y |
| S.cerevisiae genes without pombe homologues (decidedly incomplete) | Gene product or protein function | |||
|---|---|---|---|---|
| IME1 | Transcription factor, required for meiosis | |||
| RME1 | Zinc finger protein | |||
| SPO13 | meiosis regulator | |||
| MSH4 | recombination factor required in meiosis | |||
| MSH5 | recombination factor required in meiosis | |||