Goin' fission....

Gene Conversion Table

About this page: This table was intended to provide a quick translation from S. pombe to S. cerevisiae homologues prior to the genome publication and curation. It is no longer maintained but is left here because it may be helpful in some circumstances. For details and most up to date information, we suggest you go to genedb. There is also a group particularly interested in orthologues to which you can subscribe here: http://publists.sanger.ac.uk/mailman/listinfo/yeast_orthologous_group

Fission yeast genes are listed alphabetically under just one name, but their aliases are listed alongside. If you can't find the gene you want in its alphabetical position, use the search feature of your browser to see if it is listed under a synonym. One yeast may have a pair of genes where the other has just one. These cases are indicated by the word "and"; otherwise multiple gene names are aliases. In a few cases, the same gene designation may have been used for different genes which we have noted.

Recall that just because there is a cerevisiae homologue of a pombe gene doesn't mean they work the same way, and that genes without primary sequence homology can be functional homologues.

Stacks Image 126
S. pombe gene
and aliases
S. cerevisiae
sequence homologue(s)
Fission yeast gene product or protein functionMetazoan
(definitely incomplete!)
abp1+ no homologue CENP-B homologue; see cbh1+ and cbh2+Y
abt2+ TUB3 alpha tubulin (a2); not essentialY
ade6+ ADE2phosphoribosylaminoimidazole carboxylase
alp2+ SPC97 gamma-tubulin interactor
alp4+ SPC98 gamma-tubulin interactor
alp6+ GCP3 gamma-tubulin interactor
slp16+ GCP6 gamma-tubulin interactor
apc10+ APC10 APC subunitY
ark1+ IPL1 Aurora kinaseY
atb2+ alp2+ ban5+ tub1+ TUB3 alpha-2 tubulin; see also nda2+
btf3+ EGD1 and BTT1 binds nascent RNAs
byr1+ ste1+ STE7 MAPKKK, pheromone signallingY
byr2+ STE11 MAPKK, pheromone signallingY
byr4+ BYR4? With Cdc16p, a two-component GEF for the GTPase spg1 (involved in cytokinesis)
cbh1+ no homologue CENP-B homologue; see cbh2+ and apb1+Y
cbh2+ no homologue CENP-B homologue; see cbh1+ and abp1+Y
cdc1+ HYS2/HUS2/POL31/SDP5 DNA pol delta subunit
cdc2+ CDC28 CDKY
cdc3+ PFY1 profilinY
cdc4+ KAP122/PDR6myosin light chainY
cdc5+ CEF1 MYB-type splicing factorY
cdc6+ pol3+ pold+ POL3 /CDC2 DNA polymerase deltaY
cdc7+ CDC15 septation kinase
cdc8+ TPM1 and TPM2 tropomyosinY
cdc10+ SWI6 G1 phase transcription factor
cdc11+ NUD1 required for cytokinesis
cdc12+ BNI1 required for actin ring assembly
cdc13+ CLB1, CLB2, CLB3, and CLB4 B type cyclin, M phase. Essential.Y
cdc14+ no homologue required for septation
cdc15+ HOF1/YMR032wp required for septation
cdc16+ BUB2 checkpoint/cytokinesis protein. With Byr4, part of the GEF for spg1
cdc17+ CDC9 DNA ligaseY
cdc18+ CDC6 S phase initiator / MCM loaderY
cdc20+ pol2+ pole+ POL2 pol epsiolonY
cdc22+ RNR1 lg subunit ribonucleotide reductaseY
cdc23+ MCM10/DNA43 S phase factor
cdc24+ no homologue required for completion of S phase, possibly in Okazaki fragment maturation
cdc25+ MIH1 CDK tyrosine phosphataseY
cdc27+ POL32 DNA pol delta subunit
cdc28+ prp8+ no homologue helicase
cdc45+ sna41+ goa1+ CDC45 replication initiation factorY
cdm1+ no homologue?? DNA pol delta subunit
cds1+ RAD53 checkpoint kinase; not essential in pombeY
cdt1+ TAH11/SID2 required for replication initiationY
cek1+ RIM15 kinase
cgs1+ BCY1 regulatory subunit of PKA
cgs2+ pde1+PDE1 and PDE2 cAMP phosphodiesterase
chk1+ rad27+ CHK1 checkpoint kinase, damage responseY
chp1+ ? chromodomain protein, required for centromere function
chp2+ clo2+ no homologuechromodomain protein, related to Swi6p and HP1Y
cig1+ ? B-type cyclin, function not clear. Not essential. See cdc13+
cig2+ CLB5 and CLB6 B-type cyclin in S phase, not essential. See cdc13+
clp1+ cfh1+ flp1+CDC14phosphatase, involved in septation. Not essential in pombe
clr1+no homologueDNA binding protein
clr3+ HDA1histone deacetylase
clr4+ no homologuehistone H3 methyl transferaseY; Drosphila Su(var) 3-9
clr6+RPD3Histone deacetylaseY
cmb1+no homologueMismatch and damage recognition/HMG protein
cnd1+ YCS4/LOC7condensin subunit; XCAP-D2Y
cnd2+ BRN1 condensin subunit; XCAP-HY
cnd3+ YCG1/TIE1/YCS5 condensin subunit; XCAP-GY
cnp1+ CSE4 CENP-A homologue; centromere specific H3 histoneY
cps1+ drc1+ GLS1 and GLS2 1,3-(beta)-glucan synthase.
csk1+ CAK/CIV1 CAK-activating kinase Y
csn1+no homologueSignalosome subunit 1Y
csn2+no homologueSignalosome subunit 2Y
csn4+no homologueSignalosome subunit 4Y
csn5+ RRI1Signalosome subunit 5Y
csn7+no homologueSignalosome subunit 7Y
ctf18+ chl12+CTF18/CHL12RFC-1 related protein required for chromosome transmission
ctr4+ CTR1 and CTR3 High affinity copper transporter
cuf1+ MAC1 Copper-sensing transcription factor
cuf2+ no homologue?Metal ion homeostasis protein
cut1+ ESP1 promotes anaphase. Separin.
cut2+ PDS1 APC substrate, blocks cut1. Securin.
cut3+ SMC4 condensin, SMC4 subunitY
cut4+ APC1 APC subunitY
cut6+ ACC1 acetyl coA carboxylase
cut7+ CIN8 and KIP1kinesinY
cut8+ DBF8 ? regulates APC?
cut9+ CDC16 APC subunitY
cut11+ NDC1 nuclear envelope protein at SPBs and NPCs
cut12+ no homologue required for spindle formation
cut14+ SMC2 condensin, SMC2 subunitY
cut17+ bir1+ BIR1 Bir1/Survivin, chromosomal passenger proteinY
cut20+ lid1+APC4 APC subunitY
cut23+ CDC23/APC8 TPR-protein, APC componentY
cyr1+ git2+CYR1 adenylate cyclase
dfp1+ him1+ rad35+ DBF4 regulatory subunit of CDC7-type kinaseY
dhc1+DYN1 dynein motor protein
dim1+ DIB1 Required for mitosis.
Note the designation Dim1 was used later for a different gene encoding a dimethylase.
dis1+STU1 TOG-family microtubule associated proteins (also see Mtc1/Alp14)Y
dis2+ GLC7PPI-class phosphatase. Also see Sds21
dmc1+ DMC1 meiosis specific Rhp51 (RAD51) homologue, presumed required for meiotic pairing
dna2+ DNA2 helicaseY
drc1+DRC1/SLD2 CDK target, binds Rad4/Cut5, required for S phase.
eso1+CTF7/ECO1 (C-terminal)
RAD30 (N-terminal)
Required for sister chromatid cohesion and possibly for repair. A gene fusion: the C-terminus looks like CTF7/ECO1, and the N-terminus looks like RAD30Y
exo1+EXO1Mismatch repair/5' to 3' exonuclease
git3+ GPR1 G protein coupled glucose receptors
gpa1+ GPA1 G protein alpha subunit in pheromone signalling
gtb1+ TUB4 gamma tubulin
hcn1+ CDC26 APC subunit
hda1+ hoc1+ phd1+ RPD3 histone deacetylase; related to clr6+
his1+ HIS1ATP phosphoribosyltransferase
his2+ HIS4C histidinol dehydrogenase
his3+ HIS5histidinol-phosphate aminotransferase
his5+ HIS3imidazoleglycerol-phosphate dehydratase
his7+ HIS4Aphosphoribosyl-AMP cyclohydrase
hhp1+ and hhp2+ HRR25 CK-related kinases;  role in repair?
hsk1+ CDC7 DDK: DBF4-Dependent KinaseY
hus1+ MEC3 Checkpoint factor, also in metazoans. Complex with rad1, 9Y
ibp1+ YGR203W small Cdc25-like phosphatase?
imp1+ SPR1nuclear transport factor
kap104+ KAP104nuclear transport factor
kap114 KAP114nuclear transport factor
klp2+ KAR3 kinesin motor; redundant with pkl1+
klp3+ no homologue kinesin motor
klp5+ and klp6+ KIP3 kinesin motors involved in MT dynamics
klp7+ no homologue kinesin motor
klp8+ no homologue kinesin motor
leu1+ LEU2 beta-isopropylmalate dehydrogenase
lys1+ LYS2 alpha-aminoadipate reductase
mal3+BIM1 EB1 homologueY
mcm2+ cdc19+ nda1+ MCM2 MCM complex subunitY
mcm3+ MCM3 MCM complex subunitY
mcm4+ cdc21+ MCM4/CDC54 MCM complex subunitY
mcm5+ nda4+ MCM5/CDC46 MCM complex subunitY
mcm6+ mis5+ MCM6 MCM complex subunitY
mcm7+ MCM7/CDC47 MCM complex subunitY
mcs2+ CCL1 cyclin H, forms CAK with mcs6; essential for viabilityY
mcs4+ SSK1 response regulator
mcs6+ mop1+ crk1+ KIN28 CDK7, forms CAK (CDK-activating kinase)Y
mdm12+ MDM12 mitochondrial morphology/inheritance component
mek1+ MEK1 Meiosis-specific Cds1 (RAD53) homologue
mei2+ no homologueRNA binding protein required for meiosis
mei3+ no homologueactivator of meiosis: inhibits Pat1 kinase
meu13+ HOP2Required for meiotic recombination and pairing
mik1+ SWE1 CDK tyrosine kinase. Overlaps with wee1+; both are related to SWE1.
mis4+ SCC2 adherin; required for cohesin to associate with chromatin
mis6+ CTF3 inner centromere protein
mis12+ MTW1inner centromere protein
mph1+ MPS1 kinase, part of spindle checkpoint
mpr1+ ypd1+YPD1 response regulator phosphotransferase
mrc1+MRC1 Checkpoint/replication factor, works with Cds1claspin
msh2+ swi8+ mut3+MSH2Mismatch repair/mating-type switchingY
msh6+MSH6Mismatch repairY
mst1+ESA1MYST-family histone acetyltransferaseY
mst2+SAS2 and SAS3MYST-family histone acetyltransferaseY
mtc1+/alp14+STU1 TOG-family microtubule associated proteins (also see dis1+)Y
mts2+ YTA1 proteosome subunit
mts3+ NIN1 proteosome subunit
mus81+ MUS81 involved in recombination
nda2+ TUB1 major alpha tubulinY
nda3+ TUB2 beta tubulinY
ndc80+ NDC80 centromere-associated spindle componentY, human HEC
nim1+ cdr1+ no homologue? kinase regulates wee1
nuc2+ CDC27 APC subunitY
nuf2+ NUF2 centromere-associated spindle componentY
nup40+ NUP53 Nucleoporin
nup189+ NUP145 nucleoporin
orp1+ ORC1 Origin Recognition Complex subunitY
orp2+ ORC2 Origin Recognition Complex subunitY
orp3+ ORC3 Origin Recognition Complex subunitY
orp4+ ORC4 Origin Recognition Complex subunitY
orp5+ ORC5 Origin Recognition Complex subunitY
orp6+ ORC6 Origin Recognition Complex subunitY
pat1+ no homologue? (loosely related to SKS1 and other PKs) essential kinase inhibitor of meiosis
pch1+ no homologue? C-type cyclin, essential for viabilityY, C type cyclins
pcn1+ POL30 PCNAY
php2+ HAP2 carbon-source responsive transcription factor
php5+ HAP5 carbon-source responsive transcription factor
pic1+ SLI15 INCENP kinetochore proteinY
pin1+ ESS1 prolyl isomeraseY
pka1+ TPK1, TPK2 and TPK3 protein kinase AY
pkl1+ KAR3 kinesin motor; redundant with klp2+
pms1+ mlh1+ PMS1 mismatch repair protein Y
pob1+ BOI1 and BOI2required for cytokinesis
pol1+ swi7+ pola+ POL1/CDC17 DNA polymerase alphaY
pop1+ CDC4 like sud1+; SCF
pot1+ no homologue? protects telomere endsY
ppe1+ SIT4 protein phosphatase
prp2+ MUD2 large subunit splicing factor U2AF
prp4+ no homologue kinase required for splicing
prp31+ PRP31 splicing factorY
psm1+ smc1+SMC1 cohesin subunitY
psm3+ smc3+ SMC3 cohesin subunitY
psc3+ SCC3 cohesin subunitY
puc1+ CLN3?? cyclin, not essential. Acts in G1 at cell cycle entry/exit
rad1+ RAD17 Checkpoint factor Y
rad2+ RAD27, RTH1 FEN1 nucleaseY
rad3+ MEC1 ATR(ATM) checkpoint kinaseY
rad4+ cut5+ DPB11 checkpoint and replication factorY; TopBP1 or XMus101
rad9+ DDC1 Checkpoint factor Y
rad11+ rpa1+ ssb1+RPA1 large subunit RPAY
rad13+ RAD2 excision repair protein
rad15+ rhp3+ rad5+ RAD3TFIIH subunit involved in NER and transcription
rad16+ rad10+ rad20+ swi9+ RAD1NER protein
rad17+ RAD24 checkpoint protein, RFC1 related
rad18+ RHC18SMC-like protein involved in several repair processes
rad21+ MCD1 cohesinY
rad22+ and rti1+RAD52 RAD52 recombination proteinsY
rad24+ BMH1 14-3-3 proteinY
rad25+ BMH2 14-3-3 protein
rad26+ DDC2checkpoint factor
rad32+ MRE11Repair nucleaseY
ras1+ RAS1 and RAS2 ras homologue, not essentialY
rdh54+ RDH54, TID1 meiosis specific Rhp54 (RAD54) homologue Y
rec8+ REC8 meiotic cohesin, rad21+ homologue
rec12+ SPO11 meiotic early-recombination protein
rep1+ no homologue? meiosis-activator of cdc10 transcription factor
rep2+ no homologue? activator of cdc10 transcription factor
res1+ sct1+ SWI4 partner to cdc10 transcription factor
res2+ MBP1 partner to cdc10 transcription factor
rfc1+ RFC1 Replication factor -C large subunitY
rfc3+ RFC3 Replication factor -C subunit 3Y
rhp4a+ and rhp4b+
Incorrect nomenclature
Recommended is rhp41 and 42
RAD4nucleotide-excision repair
rhp6+ RAD6 UBC2 repair protein Y
rhp9+ crb2+RAD9Checkpoint proteinY?
rhp14+RAD14nucleotide-excision repair
rhp16+RAD16NER protein
rhp26+ RAD26 NER protein, SWI2/SNF2 family Y
rhp51+RAD51recombination repair
rhp54+RAD54recombination repair
rhp55+ RAD55recombination repair
rpa2+ ssb2+ RPA2 RPA subunit Y
rpa3+ ssb3+ RPA3 RPA subunit
rqh1+ rad12+ hus2+SGS1 RecQ type helicase, BLM/WRN homologueY
rti1+ no homologue 2nd RAD52 homologue
rum1+no homologue CDK inhibitor; functionally similar to SIC1
sds1+GLC7 PPI-class phosphatase (see dis2)
sfc1+TFC1 TFCIII subunit required for polIII transcription
sfc3+TFC3 TFCIII subunit required for polIII transcription
sfc4+TFC4 TFCIII subunit required for polIII transcription
sfc6+TFC6 TFCIII subunit required for polIII transcription
sid2+DBF2 and DBF20 kinase, for septation/cytokinesis
skb1+ HSL7 protein methyltransferaseY
skp1+ gsk3+ GSK3 glycogen synthase kinaseY
sla1+LHP1 La protein binds nascent pol III transcripts
sld3+ SLD3 Replication factor
slm9+ HIR2 Synthetic lethal with cdc25
slp1+ CDC20 APC activator (Fizzy)Y
SPAC1B1.03cKAP95nuclear transport factor
SPCC1322.06 KAP120nuclear transport factor
SPAC22G7.02 KAP122nuclear transport factor
SPBC14F5.03C KAP123nuclear transport factor
sal3+ PSE1 KAP121nuclear transport factor
SPBC30B4.05 CSE1nuclear transport factor
SPCC18B5.07cNUP2 nucleoporin
SPAC22G7.09c NUP49 nucleoporin
SPBC19G7.15 NUP57 nucleoporin
SPBC428.01c NUP84 nucleoporin
SPBC17G9.04c NUP85 nucleoporin
SPBC3B9.16c NUP120 nucleoporin
SPAC1805.04 NUP133 nucleoporin
SPAC23D3.06c NUP159 nucleoporin
SPCC290.03c NUP192 nucleoporin
SPAC26A3.15c NSP1 nucleoporin
SPAC15F9.02SEH1 nucleoporin
SPBC28F2.02YOR091W Nuclear pore complex-associated
SPCC162.08 MLP1Nuclear pore complex-associated
SPAC2C4.11cYOR145CNuclear pore complex-associated
SPCC4B3.07 YOR051WNuclear pore complex-associated
spc1+ sty1+ phh1+HOG1 MAPK, downsream of 2 component response regulator
spc24+SPC24 centromere-associated spindle component
spg1+ TEM1 GTPase, involved in septation and mitotic exit
spk1+ FUS3 MAPK, pheromone signalling
SPAC3C7.06c IME2 ? putative protein kinase
srw1+ ste9+ HCT1/CDH1 APC activator, WD protein
suc1+ CKS1 small CDK associated proteinY
suc22+ RNR2 small subunit ribonucleotide reductase
sud1+ CDC4 like pop1+; SCF
swi1+ TOF1 required for mating type switching and replication fork pausing
swi3+ CSM3required for mating type switching and replication fork pausing
swi4+MSH3 Mating-type switching
swi5+SAE3 Mating-type switching, recombination in meiosis and mitosisY
swi6+ no homologue chromodomain protein, HP1 relatedY
swi10+ RAD10 NER and mating-type switching
taz1+ no homologue? binds telomeres; pombe equivalent of TRF1/2?Y
tea1+ no homologue?involved in cell polarity
tea2+ KIP2 kinesin motor/cell morphology
tel1+ TEL1 ATM-related kinase (see rad3+)
trt1+ EST2 catalytic subunit of telomerase
tup11+ and tup12+ TUP1 co-repressor proteins
uap2+ CUS2 U2 snRNP associated protein
ura4+ URA3orotidine 5'-phosphate decarboxylase
wee1+ SWE1 CDK tyrosine kinase. Not essential. Overlaps with mik1+Y

S.cerevisiae genes without pombe homologues
(decidedly incomplete)
Gene product or protein function
IME1 Transcription factor, required for meiosis
RME1 Zinc finger protein
SPO13 meiosis regulator
MSH4 recombination factor required in meiosis
MSH5 recombination factor required in meiosis